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Abstract
Injured patients with Candida antigen titres have increased mortality due to sepsis.
Polymorphonuclear leucocytes (PMNs) from injured patients with elevated Candida antigen
titres demonstrate impaired function against Candida albicans growth when compared with PMNs from injury matched controls. To determine if PMN
dysfunction is global, PMNs from patients with positive Candida antigen titres were
evaluated for their ability to activate the anticandidal function of normal PMNs (autocrine
activation) and to produce tumour necrosis factor (TNF) and interleukin 8 (IL8), known
activators of PMN anticandidal function, this study demonstrates that the PMN dysfunction
is not global, as PMN cytokine production and autocrine activation remain intact.
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Article info
Publication history
Accepted:
July 9,
1997
Footnotes
☆Presented at the Eighth Scientific Assembly of the Eastern Association for the Surgery of Trauma, Sanibel, Florida, USA, 15th January 1995.
Identification
Copyright
© 1998 Published by Elsevier Inc.