Paper| Volume 28, ISSUE 3, P199-202, April 1997

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The development of the growth plate after birth: a study by osteocalcin immunocytochemistry

  • O.O.A. Oni
    Requests for reprints should be addressed to: Mr O. O. A. Oni, The Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.
    The Glenfield Hospital, Groby Road, Leicester, UK
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      The post natal development of the growth plate was studied in the rabbit lower limb using an immunocytochemical technique which localized osteocalcin in situ. At birth, there is poor colummar organization of the physis and bone is not produced. Instead the predominant activity is cartilage remodelling. The columnar architecture develops later when endochondral ossification is also observed.
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        • Salter RB
        • Harris WR
        Injuries involving the epiphyseal plate.
        J Bone Joint Surg [Am]. 1963; 45A: 587
        • Ogden JA
        2nd Ed. Skeletal Injury in the Child. Lea and Febiger, Philadelphia1982
        • Stafford H
        • Oni OOA
        • Hay J
        • Greegg PJ
        An investigation of the contribution of the extraosseous tissues to the diaphyseal fracture callus using a rabbit tibial fracture model and in situ immunocytochemical localisation of osteocalcin.
        J Orthop Trauma. 1992; 6: 190
        • Stafford HJ
        • Roberts MT
        • Oni OO
        • Hay J
        • Greegg PJ
        Localisation of bone-forming cells during fracture healing by osteocalcin immunocytochemistry: an experimental study of the rabbit tibia.
        J Orthop Res. 1994; 12: 29
        • Ham AW
        • Cormack DH
        2nd Ed. Histophysiology of Cartilage, Bone, and Joints. Lippincott, Philadelphia1979
        • Iannotti JP
        Growth plate physiology and pathology.
        Orthop Clin North Am. 1990; 21: 1
        • Robertson WW
        Newest knowledge of the growth plate.
        Clin Orthop. 1990; 253: 270
        • Hunziker EB
        Mechanism of longitudinal bone growth and its regulation by growth plate chondrocytes.
        Microsc Res Tech. 1994; 28: 505
        • Rodriguez JI
        • Razquin S
        • Palacios J
        • Rubio V
        Human growth plate development in the foetal and neonatal period.
        J Orthop Res. 1992; 10: 62
        • Hauschka PV
        • Lian JB
        • Gallop PM
        Direct identification of the calcium-binding amino acid, γ-carboxyglutamate, in mineralized tissue.
        in: 2nd Ed. Proc Natl Acad Sci USA. 72. 1985: 3925
        • Rogers LF
        • Poznanski AK
        Imaging of epiphyseal injuries.
        Radiology. 1994; 191: 291
        • Roach HI
        Trans-differentiation of hypertrophic chondrocytes into cells capable of producing a mineralized bone matrix.
        Bone Miner. 1992; 19: 1
        • LaCroix P
        The internal remodelling of bones.
        in: Bourne GH The Biochemistry and Physiology of Bone. Academic Press, New York1971