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The post natal development of the growth plate was studied in the rabbit lower limb using an immunocytochemical technique which localized osteocalcin in situ. At birth, there is poor colummar organization of the physis and bone is not produced. Instead the predominant activity is cartilage remodelling. The columnar architecture develops later when endochondral ossification is also observed.
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Accepted: November 4, 1996
© 1997 Published by Elsevier Inc.