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This study in 8 injured patients, 4 of whom were also paralysed showed that:—
- 1.Identical increased sedimentation rates, increased concentrations of α2 globulins, and increased rates of catabolism of albumin were observed in both the paralysed and non-paralysed patients following reparative surgery of a fractured tibia and fibula or extensive decubital ulcers.
- 2.Plasma albumin concentrations were subnormal in both groups of patients following the operations.
- 3.The paralysed patients showed an extravascular content of albumin which was about twice that found in normal individuals. The extravascular content of albumin in the non-paralysed injured patients was only slightly elevated above normal.
- 4.The limits of the rate of synthesis of albumin were subnormal in both the paralysed and non-paralysed patients except during a few days immediately after the operation.
- 5.The significance of these results in the absence of an intact nerve pathway from the site of injury is discussed.
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