This paper is only available as a PDF. To read, Please Download here.
Some ventilatory parameters and the factors regulating the oxygen-supply to the tissues
have been investigated in 10 patients with severe skin burns without any initial signs
of pulmonary or facial burn trauma. Special attention was paid to the system regulating
the oxygen-releasing capacity of haemoglobin.
The results indicate that periods of refractory respiratory insufficiency often occur
in severe burns. The oxygen supply to the tissues during these periods is regulated
not only by changes in blood-flow and the haemoglobin mass but also by variations
in the oxygen-releasing capacity of the haemoglobin molecule at any given tissue oxygen
tension. This release is determined by the diphosphoglycerate (2,3-DPG) content of
the erythrocytes and to a lesser extent the content of adenosine triphosphate (ATP).
Both of these compounds influence the oxyhaemoglobin dissociation equilibrium thereby
making more or less erythrocyte oxygen available to the tissues. Thus changes in the
content of erythrocyte 2,3-DPG and ATP afford indirect information about the oxygen-releasing
capacity of the circulating haemoglobin mass and the regulatory efforts to maintain
a constant tissue oxygen tension. The importance of careful monitoring of the cardiovascular
and respiratory functions in burned patients is stressed. Early diagnosis after the
onset of disturbances and prompt treatment is essential.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to InjuryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Bergmeyer H.-O. Methoden der Enzymatischen Analyse. Verlag Chemie, Weinheim1962: 539
- Bergmeyer H.-O. Methoden der Enzymatischen Analyse. Verlag Chemie, Weinheim1962: 573
- Analysis of 38 Deaths from Burns (1951–1962).Acta chir. scand. 1964; 128: 25
- - (1969), to be published.
- The Content of 2,3-diphosphoglycerate and Adenosine Triphosphate in Erythrocytes from Patients with Skin Burns.Forsvarsmed. 1969; 5: 260
- Displacements of the Oxyhemoglobin Dissociation Curve.Scand. J. clin. Lab. Invest. 1968; 22: 171
- Oxygen Consumption and Water Loss during Treatment of Burns with Warm, Dry Air.Lancet. 1968; 1: 164
- Human Red Cell Glycolytic Intermediates.J. biol. Chem. 1959; 234: 449
- The Effect of Organic Phosphates from the Human Erythrocyte on the Allosteric Properties of Hemoglobin.Biochem. biophys. Res. Commun. 1967; 26: 162
- Intracellular Organic Phosphates as Regulators of Oxygen Release by Hemoglobin.Nature, Lond. 1969; 221: 618
- Reciprocal Binding of Oxygen and Diphosphoglycerate by Human Hemoglobin.in: Proc. natn. Acad. Sci., U.S.A.59. 1968: 526
- Alterations in Metabolic Energetics and Cation Transport during Aging of Red Cells.J. clin. Invest. 1959; 38: 1572
- The Adenosine Triphosphate Content of Glucose-6-phosphate Dehydrogenase-deficient and Normal Erythrocytes, including Studies of a Glucose-6-phosphate Dehydrogenase-deficient Man with Elevated Erythrocytic ATP.J. Lab. clin. Med. 1966; 67: 726
- Hemoglobin Functions in Stored Blood.J. clin. Invest. 1969; 48: 311
- The Effect of Organic and Inorganic Phosphates on the Oxygen Equilibrium of Human Erythrocytes.Archs Biochem. Biophys. 1967; 121: 96
- Continuous Recording of Blood Oxygen Tensions by Polarography.J. appl. Physiol. 1953; 6: 189
- Metabolic Rate and Thyroid Function following Acute Thermal Trauma in Man.Ann. Surg. 1953; 137: 163
- Improved Oxygen Release: an Adaptation of Mature Red Cells to Hypoxia.J. clin. Invest. 1968; 47: 1851
- Electrolyte-labile Increase of Oxygen Affinity during in vivo Aging of Hemoglobin.J. clin. Invest. 1967; 46: 1579
- Binding of ATP and 2,3-DPG to Hemoglobin —Effect on Erythrocyte Glycolysis.Folia haemat., Lpz. 1968; 89: 421
- Binding of Phospho-compounds to Haemoglobin.Forsvarsmed. 1969; 5: 163
- The Effect of Shock on Pulmonary Alveolar Surfactant. Its Role in Refractory Insufficiency of the critically Ill or severely Injured Patient.J. Trauma. 1968; 8: 756
- The Content of Some Glycolytic Intermediates and Cofactors in Human Erythrocytes from Adults and Neonates.Acta Univ. upsal. 1969; (Abstract of Uppsala Dissertations in Medicine)
- Effect of Altitude on Oxygen Binding by Hemoglobin and Organic Phosphate Levels.J. clin. Invest. 1969; 47: 2652
- An Analysis of the Effect of Burn Therapy on Burn Mortality.in: Artz C. Research in Burns. Davis, Philadelphia1962: 10
- The Aging of Red Cells.J. Physiol. 1958; 143: 325
- The Oxyhemoglobin Dissociation Curve in Anaemia.Ann. intern. Med. 1960; 52: 295
- The Purification and Properties of Diphosphoglycerate Mutase from Human Erythrocytes.J. biol. Chem. 1968; 243: 4810
- Kinetik des 2, 3 Disphosphoglyceratumsatzes in Menschlichen Erythrocyten.Biochem. Z. 1965; 341: 387
- The Relationship of Adenosine Triphosphate Concentration to Erythrocyte Aging.J. Lab. clin. Med. 1968; 71: 41
- The Acid-base Status of the Blood.3rd ed. Munksgaard, Copenhagen1967
- Purification and Characterization of Diphosphoglycerate Phosphatase from Human Erythrocytes.Folia haemat., Lpz. 1968; 90: 215
- Intraerythrocytic Regulation of Tissue Oxygen Tension.Acta Soc. Med. upsal. 1969; 72: 209
- Storage of Human Red Blood Cells. I. The Effect of ACD Solutions on the Breakdown of Glucose.Acta physiol. scand. 1962; 54: 346
Article info
Identification
Copyright
© 1970 Published by Elsevier Inc.
