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Research Article| Volume 1, ISSUE 3, P178-185, January 1970

Fibrinogen metabolism following injury and its surgical treatment

  • J.W.L. Davies
    Correspondence
    Requests for reprints should be addressed to:—J.W.L. Davies, Esq., Ph.D., M.R.C. Industrial Injuries and Burns Research Unit, Birmingham Accident Hospital, Bath Row, Birmingham 15, England.
    Affiliations
    M.R.C. Industrial Injuries and Burns Research Unit, Birmingham Accident Hospital, King Gustaf V Research Institute and the Surgical and Medical Departments, Karolinska Sjukhuset, Stockholm, Sweden
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  • S.-O. Liljedahl
    Affiliations
    M.R.C. Industrial Injuries and Burns Research Unit, Birmingham Accident Hospital, King Gustaf V Research Institute and the Surgical and Medical Departments, Karolinska Sjukhuset, Stockholm, Sweden
    Search for articles by this author
  • P. Reizenstein
    Affiliations
    M.R.C. Industrial Injuries and Burns Research Unit, Birmingham Accident Hospital, King Gustaf V Research Institute and the Surgical and Medical Departments, Karolinska Sjukhuset, Stockholm, Sweden
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DOI:https://doi.org/10.1016/S0020-1383(70)80040-7
Fibrinogen metabolism following injury and its surgical treatment
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      Studies with radioactively labelled fibrinogen given to elderly and young injured patients subjected to reparative surgery showed that:—
      • 1.
        The actual amount of labelled protein (mg. per kg.) catabolized per day was increased to between 2 and 3 times normal, in both the young and elderly patients.
      • 2.
        In elderly injured patients more radioactivity was found outside the active circulation than found outside the circulation of young injured patients or in normal persons. This radioactivity outside the circulation had a longer biological half-life than that of the plasma fibrinogen, suggesting that the non-circulating radioactivity was attached to fibrin.
      • 3.
        The rate of synthesis of fibrinogen was increased in both the young and elderly injured patients.
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      Article info

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      DOI: https://doi.org/10.1016/S0020-1383(70)80040-7

      Copyright

      © 1970 Published by Elsevier Inc.

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