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Research Article| Volume 54, ISSUE 1, P19-24, January 2023

Prediction of massive transfusion with the Revised Assessment of Bleeding and Transfusion (RABT) score at Canadian level I trauma centers

  • Karan D'Souza
    Correspondence
    Corresponding author at: Section of Acute Care Surgery and Trauma, Division of General Surgery Gordon & Leslie Diamond Health Care Centre, 11th floor 2775 Laurel St, Room 11123, Vancouver, BC, Canada V5Z 1M9.
    Affiliations
    Section of Acute Care Surgery and Trauma, Division of General Surgery, Department of Surgery, University of British Columbia, Vancouver, BC, Canada

    Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
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  • Mathew Norman
    Affiliations
    Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
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  • Adam Greene
    Affiliations
    AirEvac and Critical Care Operations, British Columbia Emergency Health Services, Vancouver, BC, Canada
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  • Colby J.F. Finney
    Affiliations
    Section of Acute Care Surgery and Trauma, Division of General Surgery, Department of Surgery, University of British Columbia, Vancouver, BC, Canada

    Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

    AirEvac and Critical Care Operations, British Columbia Emergency Health Services, Vancouver, BC, Canada

    Department of Orthopaedics, University of British Columbia, Vancouver, BC, Canada

    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

    Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
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  • Matthew T.S. Yan
    Affiliations
    Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

    AirEvac and Critical Care Operations, British Columbia Emergency Health Services, Vancouver, BC, Canada
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  • Jacqueline D. Trudeau
    Affiliations
    Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

    Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
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  • Michelle P. Wong
    Affiliations
    Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
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  • Andrew Shih
    Affiliations
    Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
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  • Philip Dawe
    Affiliations
    Section of Acute Care Surgery and Trauma, Division of General Surgery, Department of Surgery, University of British Columbia, Vancouver, BC, Canada

    Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
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Published:September 17, 2022DOI:https://doi.org/10.1016/j.injury.2022.09.022

      Abstract

      Background

      Early damage control resuscitation and massive transfusion (MT) protocol activations improve outcomes in trauma patients with hemorrhagic shock, where scores to guide MT prediction are used including: the Assessment of Blood Consumption (ABC), Shock Index (SI), and Revised Assessment of Bleeding and Transfusion (RABT) scores. Our aim was to validate the RABT score in patients from two level I trauma centers in Canada.

      Methods

      A retrospective review of adult patients meeting trauma team activation criteria receiving >1 unit of red blood cells (RBCs) within 24 h of admission, from 2015 to 2020, was conducted. A RABT score ≥ 2, ABC score ≥ 2, and Shock Index (SI) ≥ 1 was used to predict MT using both research (≥10 RBCs in 24 h) and clinical (≥3 RBCs in 3 h) definitions. Scores were assessed and compared using sensitivity, specificity, and the area under the receiver operating characteristic (AUROC).

      Results

      We analyzed 514 patients with a mean age of 44.4 (19.2) years and a median injury severity score of 29 [18–38]. For both MT definitions, the RABT score trended towards higher sensitivity and lower specificity compared to ABC score and SI. For both research and clinical definitions of MT, the AUROC for the RABT score was not significantly higher (Research - RABT: 0.673 [0.610–0.735], ABC: 0.642 [0.551–0.734], SI 0.691 [0.625–0.757]; Clinical - RABT: 0.653 [0.608–0.698], ABC: 0.646 [0.600–0.691], SI 0.610 [0.559–0.660]).

      Conclusion

      The RABT score is a valid tool for predicting the need for MTPs, performing similarly with a trend towards higher sensitivity when compared to the ABC score and SI.

      Keywords

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      References

        • Cannon J.W.
        Hemorrhagic shock.
        N Engl J Med. 2018; 378: 370-379
        • Eastridge B.J.
        • Holcomb J.B.
        • Shackelford S.
        Outcomes of traumatic hemorrhagic shock and the epidemiology of preventable death from injury.
        Transfusion. 2019; 59 (Paris): 1423-1428
        • Ball C.G.
        Damage control resuscitation: history, theory and technique.
        Can J Surg. 2014; 57: 55-60
        • Holcomb J.B.
        • Jenkins D.
        • Rhee P.
        • Johannigman J.
        • Mahoney P.
        • Mehta S.
        • et al.
        Damage control resuscitation: directly addressing the early coagulopathy of trauma.
        J Trauma. 2007; 62: 307-310
        • Tien H.C.
        • Spencer F.
        • Tremblay L.N.
        • Rizoli S.B.
        • Brenneman F.D.
        Preventable deaths from hemorrhage at a level I Canadian trauma center.
        J Trauma. 2007; 62: 142-146
        • Meyer D.E.
        • Vincent L.E.
        • Fox E.E.
        • O'Keeffe T.
        • Inaba K.
        • Bulger E.
        • et al.
        Every minute counts: time to delivery of initial massive transfusion cooler and its impact on mortality.
        J Trauma Acute Care Surg. 2017; 83: 19-24
        • Shih A.W.
        • Al Khan S.
        • Wang A.Y.
        • Dawe P.
        • Young P.Y.
        • Greene A.
        • et al.
        Systematic reviews of scores and predictors to trigger activation of massive transfusion protocols.
        J Trauma Acute Care Surg. 2019; 87: 717-729
        • Haider A.A.
        • Azim A.
        • Rhee P.
        • Kulvatunyou N.
        • Ibraheem K.
        • Tang A.
        • et al.
        Substituting systolic blood pressure with shock index in the national trauma triage protocol.
        J Trauma Acute Care Surg. 2016; 81: 1136-1141
        • Rau C.S.
        • Wu S.C.
        • Kuo S.C.H.
        • Pao-Jen K.
        • Shiun-Yuan H.
        • Yi-Chun Chen
        • et al.
        Prediction of massive transfusion in trauma patients with shock index, modified shock index, and age shock index.
        Int J Environ Res Public Health. 2016; 13: 683
        • Nunez T.C.
        • Voskresensky I.V.
        • Dossett L.A.
        • Shinall R.
        • Dutton W.D.
        • Cotton B.A.
        Early prediction of massive transfusion in trauma: simple as ABC (assessment of blood consumption).
        J Trauma. 2009; 66: 346-352
        • Pommerening M.J.
        • Goodman M.D.
        • Holcomb J.B.
        • Wade C.E.
        • Fox E.E.
        • Del Junco D.J.
        • et al.
        Clinical gestalt and the prediction of massive transfusion after trauma.
        Injury. 2015; 46: 807-813
        • Joseph B.
        • Khan M.
        • Truitt M.
        • Jehan F.
        • Kulvatunyou N.
        • Azim A.
        • et al.
        Massive transfusion: the Revised Assessment of Bleeding and Transfusion (RABT) score.
        World J Surg. 2018; 42: 3560-3567
        • Hanna K.
        • Harris C.
        • Trust M.D.
        • Bernard A.
        • Brown C.
        • Hamidi M.
        • et al.
        Multicenter validation of the Revised Assessment of Bleeding and Transfusion (RABT) score for predicting massive transfusion.
        World J Surg. 2020; 44: 1807-1816
        • Glance L.G.
        • Osler T.M.
        • Dick A.W.
        • Mukamel D.B.
        • Meredith W.
        The survival measurement and reporting trial for trauma (SMARTT): background and study design.
        J Trauma. 2010; 68: 1491-1497
        • Macpherson A.K.
        • Schull M.J.
        Penetrating trauma in Ontario emergency departments: a population-based study.
        Can J Emerg Med. 2007; 9: 16-20
        • Mann S.M.
        • Banaszek D.
        • Lajkosz K.
        • Brogly S.B.
        • Stanojev S.M.
        • Evans C.
        • et al.
        High-energy trauma patients with pelvic fractures: management trends in Ontario, Canada.
        Injury. 2018; 49: 1830-1840
        • Lawson F.L.
        • Schuurman N.
        • Oliver L.
        • Nathens A.B
        Evaluating potential spatial access to trauma center care by severely injured patients.
        Health Place. 2013; 19: 131-137
        • Tansley G.
        • Schuurman N.
        • Bowes M.
        • Erdogan M.
        • Green R.
        • Asbridge M.
        • et al.
        Effect of predicted travel time to trauma care on mortality in major trauma patients in Nova Scotia.
        Can J Surg. 2019; 62: 123-130
        • Malone D.L.
        • Hess J.R.
        • Fingerhut A.
        Massive transfusion practices around the globe and a suggestion for a common massive transfusion protocol.
        J Trauma. 2006; 60 (Suppl): S91-S96
        • Raymer J.M.
        • Flynn L.M.
        • Martin R.F.
        Massive transfusion of blood in the surgical patient.
        Surg Clin North Am. 2012; 2 (vii): 221
        • Savage S.A.
        • Zarzaur B.L.
        • Croce M.A.
        • Fabian T.C.
        Redefining massive transfusion when every second counts.
        J Trauma Acute Care Surg. 2013; 74: 396-402
      1. RStudio Team. RStudio: integrated development for R. RStudio, Inc., Boston, MA. 2021.

        • Young J.W.
        • Burgess A.R.
        • Brumback R.J.
        • Poka A.
        Pelvic fractures: value of plain radiography in early assessment and management.
        Radiology. 1986; 160: 445-451
        • Greene A.
        • Vu E.N.
        • Archer T.
        • Norman S.
        • Trojanowski J.
        • Shih A.W.
        A service evaluation of prehospital blood transfusion by critical care paramedics in British Columbia, Canada.
        Air Med J. 2021; 40: 441-445
        • Thies K.C.
        • Truhlář A.
        • Keene D.
        • Hinkelbein J.
        • Rützler K.
        • Brazzi L.
        • et al.
        Pre-hospital blood transfusion - an ESA survey of European practice.
        Scand J Trauma Resusc Emerg Med. 2020; 28: 79
        • Søreide K.
        Epidemiology of major trauma.
        Br J Surg. 2009; 96: 697-698
        • Macpherson A.K.
        • Schull M.J.
        Penetrating trauma in Ontario emergency departments: a population-based study.
        CJEM. 2007; 9: 16-20
        • Manson T.
        • O'Toole R.V.
        • Whitney A.
        • Duggan B.
        • Sciadini M.
        • Nascone J.
        Young-Burgess classification of pelvic ring fractures: does it predict mortality, transfusion requirements, and non-orthopaedic injuries?.
        J Orthop Trauma. 2010; 24: 603-609
        • Olaussen A.
        • Blackburn T.
        • Mitra B.
        • Fitzgerald M.
        Review article: shock index for prediction of critical bleeding post-trauma: a systematic review.
        Emerg Med Australas. 2014; 26: 223-228