Long-term effects of early stress due to earthquake exposure on depression symptoms in adulthood: a cross-sectional study



      This study aimed to investigate the long-term effects of early stress by Tangshan earthquake on symptoms of depression in adulthood.


      A total of 1534 volunteers born and raised in Tangshan were investigated; finally, 1328 subjects were enrolled in the study. They were divided into three groups according to their birth dates: infant exposure, prenatal exposure, and non-exposure. The questionnaires and psychological evaluation of all subjects were completed using a one-on-one psychological test.


      The rate of depressive symptoms in the prenatal exposure group was the highest, and the lowest in the non-exposure group, with statistical differences among the three groups (P = 0.002). Moreover, the incidences of depressed mood, suicide ideation and work and loss of interest in the prenatal exposure group were significantly higher than those in the infant exposure group and the non-exposure group (P = 0.008, P = 0.001, P = 0.038, respectively). Multiple logistic regression analysis showed that male could be a protective factor for symptoms of depression in adulthood, and earthquake exposure was an important predictor of the incidence of depression symptoms.


      Fetal or infancy exposure to earthquake might correlate to depression symptoms in adulthood.



      CTQ (Childhood Trauma Questionnaire), DSM-IV (Diagnostic and Statistical Manual of Mental Disorders-4th edition), HAMD (Hamilton Depression Scale), LES (Life Event Scale), MDD (major depressive disorder)
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        • van Dijkman SC
        • de Jager NCB
        • Rauwé WM
        • Danhof M
        • Della-Pasqua O
        Effect of age-related factors on the pharmacokinetics of lamotrigine and potential implications for maintenance dose optimisation in future clinical trials.
        Clin Pharmacokinet. 2018; 57: 1039-1053
        • Wittenborn AK
        • Rahmandad H
        • Rick J
        • Hosseinichimeh N.
        Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder.
        Psychol Med. 2016; 46: 551-562
        • Cao YJ
        • Wang Q
        • Zheng XX
        • Cheng Y
        • Zhang Y.
        Involvement of SNARE complex in the hippocampus and prefrontal cortex of offspring with depression induced by prenatal stress.
        J Affect Disord. 2018; 235: 374-383
        • Kingsbury M
        • Weeks M
        • MacKinnon N
        • et al.
        Stressful life events during pregnancy and offspring depression: evidence from a prospective cohort study.
        J Am Acad Child Adolesc Psychiatry. 2016; 55 (e2): 709-716
        • Weinstock M.
        The long-term behavioural consequences of prenatal stress.
        Neurosci Biobehav Rev. 2008; 32: 1073-1076
        • Norris FH
        • Sherrieb K
        • Galea S.
        Prevalence and consequences of disaster-related illness and injury from Hurricane Ike.
        Rehabil Psychol. 2010; 55: 221-230
        • Beaglehole B
        • Bloomer C
        • Zhang T
        • et al.
        The impact of the Canterbury earthquakes on dispensing for older person's mental health.
        Int J Geriatr Psychiatry. 2019; 34: 1599-1604
        • Hammen C.
        Risk factors for depression: an autobiographical review.
        Annu Rev Clin Psychol. 2018; 14: 1-28
        • Kautz MM
        • Coe CL
        • McArthur BA
        • Mac-Giollabhui N
        • Ellman LM
        • Abramson LY
        • et al.
        Longitudinal changes of inflammatory biomarkers moderate the relationship between recent stressful life events and prospective symptoms of depression in a diverse sample of urban adolescents.
        Brain Behav Immun. 2020; 86: 43-52
        • Fatima Mahino
        • Srivastav Saurabh
        • Mondal AC
        Prenatal stress and depression associated neuronal development in neonates.
        Int J Dev Neurosci. 2017; 60: 1-7
        • Caspi A
        • Sugden K
        • Moffitt TE
        • et al.
        Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.
        Science. 2003; 301: 386-389
        • Torres-Berrío A
        • Issler O
        • Parise EM
        • Nestler EJ.
        Unraveling the epigenetic landscape of depression: focus on early life stress.
        Dialogues Clin Neurosci. 2019; 21: 341-357
        • Ju Y
        • Wang M
        • Lu X
        • Sun J
        • Dong Q
        • Zhang L
        • et al.
        The effects of childhood trauma on the onset, severity and improvement of depression: the role of dysfunctional attitudes and cortisol levels.
        J Affect Disord. 2020; 276: 402-410
        • Abe H
        • Hidaka N
        • Kawagoe C
        • Odagiri K
        • Watanabe Y
        • Ikeda T
        • et al.
        Prenatal psychological stress causes higher emotionality, depression-like behavior, and elevated activity in the hypothalamo-pituitary-adrenal axis.
        Neurosci Res. 2007; 59: 145-151
        • Van den Hove DL
        • Leibold NK
        • Strackx E
        • Martinez-Claros M
        • Lesch KP
        • Steinbusch HW
        • et al.
        Prenatal stress and subsequent exposure to chronic mild stress in rats; interdependent effects on emotional behavior and the serotonergic system.
        Eur Neuropsychopharmacol. 2014; 24: 595-607
        • Lazinski MJ
        • Fau SA
        • Steiner M.
        Effects of maternal prenatal stress on offspring development: a commentary.
        Arch Womens Ment Health. 2008; 11 (-6): 363-375
        • Tian T
        • Xu B
        • Qin Y
        • Fan L
        • Chen J
        • Zheng P
        • et al.
        Clostridium butyricum miyairi 588 has preventive effects on chronic social defeat stress-induced depressive-like behaviour and modulates microglial activation in mice.
        Biochem Biophys Res Commun. 2019; 516: 430-436
        • Fatima M
        • Srivastav S
        • Ahmad MH
        • Mondal ACA-Ohoo.
        Effects of chronic unpredictable mild stress induced prenatal stress on neurodevelopment of neonates: role of GSK-3beta.
        Sci Rep. 2019; 9: 1305
        • Fatima M
        • Srivastav S
        • Mondal AC.
        Prenatal stress and depression associated neuronal development in neonates.
        Int J Dev Neurosci. 2017; 60: 1-7
        • Tu HF
        • Skalkidou A
        • Lindskog M
        • Gredebäck G.
        Maternal childhood trauma and perinatal distress are related to infants' focused attention from 6 to 18 months.
        Sci Rep. 2021; 11: 24190
        • Mareckova K
        • Klasnja A
        • Bencurova P
        • Andryskova L
        • Brazdil M
        • Paus T.
        Prenatal stress, mood, and gray matter volume in young adulthood.
        Cereb Cortex. 2019; 29: 1244-1250
        • Maccari S
        • Fau KH
        • Morley SZYF
        • Fau M
        • Brunton PJ
        The consequences of early-life adversity: neurobiological, behavioural and epigenetic adaptations.
        J Neuroendocrinol. 2014; 26: 707-723
        • Bernstein DP
        • Stein JA
        • Newcomb MD
        • Walker E
        • Pogge D
        • Ahluvalia T
        • et al.
        Development and validation of a brief screening version of the childhood trauma questionnaire.
        Child Abuse Negl. 2003; 27: 169-190
        • Mo Q
        • Zhou L
        • He Q
        • Jia C
        • Ma Z.
        Validating the life events scale for the elderly with proxy-based data: a case-control psychological autopsy study in rural China.
        Geriatr Gerontol Int. 2019; 19: 547-551
      1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th ed. Arlington, VA: American Psychiatric Publishing; 2013

        • Hamilton M
        A rating scale for depression.
        J Neurol Neurosurg Psychiatry. 1960; 23 (20Liu J, Yan F, Ma X, et al. Prevalence of major depressive disorder and socio-demographic correlates: Results of a representative household epidemiological survey in Beijing, China. J Affect Disord. 2015;179:74-81): 56-62
        • Gu L
        • Xie J
        • Long J
        • et al.
        Epidemiology of major depressive disorder in mainland china: a systematic review.
        PLoS One. 2013; 8: e65356
        • Liu J
        • Yan F
        • Ma X
        • et al.
        Prevalence of major depressive disorder and socio-demographic correlates: results of a representative household epidemiological survey in Beijing, China.
        J Affect Disord. 2015; 179: 74-81
        • Guo S
        • Tian D
        • Wang X
        • Xiao Y
        • He H
        • Qu Z
        • et al.
        Protective effects of social support content and support source on depression and its prevalence 6 months after Wenchuan earthquake.
        Stress Health. 2015; 31: 382-392
        • Du N
        • Zhou P
        • SiTu MJ
        • Zhu CZ
        • Huang Y.
        Post-traumatic stress disorder and depression symptoms of adolescents survived from a seriously-hit area in China: a 3-year follow-up study.
        Psychiatry Res. 2019; 273: 288-295
        • Parker G
        • Fletcher K
        • Paterson A
        • Anderson J
        • Hong M
        Gender differences in depression severity and symptoms across depressive sub-types.
        J Affect Disord. 2014; 167: 351-357
        • Zhang C
        • Xu D
        • Luo H
        • Lu J
        • Liu L
        • Ping J
        • et al.
        Prenatal xenobiotic exposure and intrauterine hypothalamus-pituitary-adrenal axis programming alteration.
        Toxicology. 2014; 325: 74-84
        • Izvolskaia M
        • Sharova V
        • Zakharova L.
        Prenatal programming of neuroendocrine system development by lipopolysaccharide: long-term effects.
        Int J Mol Sci. 2018; 19 (pii): E3695
        • Nederhof E
        • Schmidt MV.
        Mismatch or cumulative stress: toward an integrated hypothesis of programming effects.
        Physiol Behav. 2012; 106: 691-700
        • Weinstock M.
        Intrauterine factors as determinants of depressive disorder.
        Isr J Psychiatry Relat Sci. 2010; 47: 36-45
        • Lin T
        • Dang S
        • Su Q
        • Zhang H
        • Zhang J
        • Zhang L
        • et al.
        The impact and mechanism of methylated metabotropic glutamate receptors 1 and 5 in the hippocampus on depression-like behavior in prenatal stress offspring rats.
        J Clin Med. 2018; 7 (pii): E117
        • Abel KM
        • Heuvelman HP
        • Jörgensen L
        • Magnusson C
        • Wicks S
        • Susser E
        • Hallkvist J
        • et al.
        Severe bereavement stress during the prenatal and childhood periods and risk of psychosis in later life: population based cohort study.
        BMJ. 2014; 348: f7679