- •An increased focus on sample size calculations and adequately powered studies will allow for more robust and valid findings in clinical trials.
- •Blinding in orthopaedic trials is challenging, but there has been effort to increase blinding to reduce the risk of exaggerated effect sizes.
- •Expertise-based trials represent a novel design in surgical based trials, with the potential to reduce bias and increase validity and feasibility.
- •Patient reported outcomes and minimal important differences represent important trial outcomes that have seen increased uptake.
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This paper is part of a supplement supported by AOTrauma Europe.