Editorial| Volume 42, ISSUE 2, P117-118, February 2011

Trauma research: An opportunity and a challenge

      Injury remains the leading cause of death in children and adults under 45 and is a major cause of short- and long-term morbidity.
      • Green S.
      • Miles R.
      The Burden of Disease and Illness in the UK.
      The recent National Audit Office report on major trauma repeated longstanding criticisms of trauma care in the NHS.
      Major trauma care in England.
      The Department of Health began work to address these after the 2007 NCEPOD report Trauma-Who Cares?

      Trauma – Who Cares? National Confidential Enquiry into Patient Outcomes and Deaths; 2007.

      Less talked about is the poor state of trauma research.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Injury
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Borg T.
        • Berg P.
        • Fugl-Meyer K.
        • Larsson S.
        Health-related quality of life and life satisfaction in patients following surgically treated pelvic ring fractures. A prospective observational study with two years follow-up.
        Injury. 2010; 41: 400-404
      1. Catherine Elliott, Head of Clinical Research Support and Ethics, Medical Research Council (Personal communication).

        • Chaudhuri K.
        • Malham G.M.
        • Rosenfeld J.V.
        Survival of trauma patients with coma and bilateral fixed dilated pupils.
        Injury. 2009; 40: 28-32
        • CRASH-2 Trial Collaborators
        Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial.
        Lancet. 2010;
        • Dewar D.
        • Moore F.A.
        • Moore E.E.
        • Balogh Z.
        Postinjury multiple organ failure.
        Injury. 2009; 40: 912-918
        • Dutton R.
        • Hauser C.
        • Boffard K.
        • Dimsitts J.
        • Bernard G.
        • Holcomb J.
        • et al.
        • CONTROL Steering Committee
        Scientific and logistical challenges in designing the CONTROL trial: recombinant factor VIIa in severe trauma patients with refractory bleeding.
        Clin Trials. 2009 Oct; 6 (Epub 2009 Sep 8): 467-479
        • Giannoudis P.V.
        • Mallina R.
        • Harwood P.
        • et al.
        Pattern of release and relationship between HMGB-1 and IL-6 following blunt trauma.
        Injury. 2010; (September 29)
        • Green S.
        • Miles R.
        The Burden of Disease and Illness in the UK.
        Department of Health, 2007
      2. Health Technology Assessment. HTA Clinical Evaluation and Trials. March 2010. Available at:

        • Kent M.J.
        • Elliot R.R.
        • Taylor H.P.
        Outcomes of trauma in centenarians.
        Injury. 2009; 40: 358-361
      3. Major trauma care in England.
        National Audit Office, 2010
      4. Medical Research Council. Funding Discussions about Acute Trauma. January 2010. Available at:

      5. NHS Clinical Advisory Groups. Regional Networks for Major Trauma. October 2010. Available at:

        • Papathanasopoulos A.
        • Nikolaou V.
        • Petsatodis G.
        • Giannoudis P.V.
        Multiple trauma: an ongoing evolution of treatment modalities?.
        Injury. 2009; 40: 115-119
        • Pfeifer R.
        • Tarkin I.S.
        • Rocos B.
        • Pape H.C.
        Patterns of mortality and causes of death in polytrauma patients—has anything changed?.
        Injury. 2009; 40: 907-911
        • Probst C.
        • Pape H.C.
        • Hildebrand F.
        • et al.
        30 years of polytrauma care: an analysis of the change in strategies and results of 4849 cases treated at a single institution.
        Injury. 2009; 40: 77-83
        • Roberts I.
        • Schierhout G.
        • Alderson P.
        Absence of evidence for the effectiveness of five interventions routinely used in the intensive care management of severe head injury: a systematic review.
        J Neurol Neurosurg Psychiatry. 1998; 65: 729-733
        • Stengel D.
        • Ekkernkamp A.
        • Wich M.
        Functional outcomes and health-related quality of life after intramedullary nailing of tibia shaft fractures.
        Injury. 2009; 40: S9
      6. Trauma – Who Cares? National Confidential Enquiry into Patient Outcomes and Deaths; 2007.

        • UK Clinical Research Collaboration
        UK Health Research Analysis.
        Department of Health, 2006
        • Utomo W.K.
        • Gabbe B.J.
        • Simpson P.M.
        • Cameron P.A.
        Predictors of in-hospital mortality and 6-month functional outcomes in older adults after moderate to severe traumatic brain injury.
        Injury. 2009; 40: 973-977
      7. Wellcome Trust. Applications open for Health Innovation Challenge Fund's timely new theme. March 2010. Available at: