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Abstract
Daily serum c-reactive protein (CRP) concentration was monitored in 98 patients (26
female) admitted to the Major Injuries Unit (MIU) at Birmingham Accident Hospital
following serious trauma. The mean (SD) increase in CRP concentration for 79 survivors
and 19 non-survivors between days 1 and 2 after trauma were 69.5 (74.6) and 111.8
(59.0) mg/l/24h, respectively (P = < 0.001). By day 4 after trauma the mean serum
CRP concentrations for survivors and non-survivors were 150.9 (76.9) and 233.4 (100.8)
mg/l (P < 0.001), respectively.
Injury severity data were available for 50 patients. The mean (range) injury severity
score was 25.2 (4–50), Glasgow coma scale 10.4 (3–15), revised trauma score 6.5 (3.39–7.8)
and predicted survival 0.78 (0.02–0.99). Univariate regression analysis of serum CRP
on days 1–5 after injury against revised trauma score and injury severity score, revealed
an inverse correlation between day 1 serum CRP and Glasgow Coma Score (r = −0.306,
P < 0.05), but no correlation with injury severity score or predicted survival on
any of the study days. The lack of correlation between serum CRP and injury severity
or predicted survival, and the strong association with actual survival, suggests that
the acute inflammatory response to serious trauma and subsequent complications, is
an important determinant of outcome.
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Article info
Publication history
Accepted:
February 12,
1992
Identification
Copyright
© 1992 Published by Elsevier Inc.
