Research Article| Volume 22, ISSUE 5, P375-376, September 1991

Increased endothelial cell stimulating angiogenesis factor in patients with tibial fractures

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      Angiogenesis is an important step in the normal process of fracture healing, irrespective of the method of fixation. Using a quantitative assay, the amount of endothelial cell stimulating factor (ESAF) has been determined in a small group of patients with tibial fractures. ESAF levels were found to be increased when compared with normal volunteers, although this increase was relatively less in fractures held with intramedullary nails than with external fixation.
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