Advertisement
Research Article| Volume 22, ISSUE 5, P375-376, September 1991

Increased endothelial cell stimulating angiogenesis factor in patients with tibial fractures

      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Angiogenesis is an important step in the normal process of fracture healing, irrespective of the method of fixation. Using a quantitative assay, the amount of endothelial cell stimulating factor (ESAF) has been determined in a small group of patients with tibial fractures. ESAF levels were found to be increased when compared with normal volunteers, although this increase was relatively less in fractures held with intramedullary nails than with external fixation.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Injury
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Brown R.A.
        • Taylor C.M.
        • McLaughlin B.
        • et al.
        Identification of an angiogenic procollagenase activator from epiphyseal growth plate cartilage and mineralizing chondrocytes in culture.
        Bone Miner Res. 1987; 3: 143
        • Brown R.A.
        • Weiss J.B.
        Neovascularisation and its role in the osteoarthritic process.
        Ann. Rheum. Dis. 1988; 47: 881
        • Kessler S.B.
        • Hallfeldt K.K.J.
        • Perren S.M.
        • et al.
        The effects of reaming and intramedullary nailing on fracture healing.
        Clin. Orthop. 1986; 212: 18
        • Paradis G.R.
        • Kelly P.J.
        Blood flow and mineral deposition in canine tibial fractures.
        J. Bone Joint Surg. 1975; 57A: 220
        • Smith S.R.
        • Bronk J.T.
        • Kelly P.J.
        Effect of fracture fixation on cortical bone blood flow.
        J. Orthop. Res. 1990; 8: 471
        • Smith M.A.
        • Jones F.A.
        • Strachan R.K.
        • et al.
        Prediction of fracture healing in the tibia by quantitative radionuclide imaging.
        J. Bone Joint Surg. 1987; 69B: 441
        • Strachan R.K.
        • McCarthy I.D.
        • Fleming R.H.
        • et al.
        The role of the tibial nutrient artery.
        J. Bone Joint Surg. 1990; 72B: 391
        • Taylor C.M.
        • McLaughlin B.
        • Weiss J.B.
        • et al.
        Bovine and human pineal glands contain substantial quantities of endothelial cell stimulating factor.
        J. Neural Transm. 1988; 71: 79
        • Taylor C.M.
        • Weiss J.B.
        Raised endothelial cell stimulating angiogenic factor in diabetic retinopathy.
        Lancet. 1989; 2: 1329
        • Trueta J.
        Blood supply and rate of healing of tibial fractures.
        Clin. Orthop. 1974; 105: 11
        • Weiss J.B.
        • Hill Cr.
        • Davis R.J.
        • et al.
        Activation of procollagenase by a low molecular weight angiogenesis factor.
        Biosci. Rep. 1983; 3: 171
        • Zetter B.R.
        Angiogenesis: state of the art.
        Chest. 1988; 93: 159S