Paper| Volume 22, ISSUE 2, P114-116, March 1991

Intrapleural bupivacaine analgesia in chest trauma: a randomized double-blind controlled trial

      This paper is only available as a PDF. To read, Please Download here.


      A randomized double-blind study was undertaken to investigate whether 0.25 per cent bupivacaine administered intrapleurally is an effective and reasonably safe method of obtaining analgesia in patients with thoracic injuries, A total of 120 patients complaining of pain after chest injury were entered into the trial All had thoracostomy tubes already in situ. Of 60 patients who were given the test dose of bupivacaine intrapleurally, 37 obtained satisfactory pain relief for 2 or more hours compared with only 9 of 60 patients who received saline P < 0.000001). Duration of analgesia in the test group (mean 3.9 h) was significantly longer than that in the control group (mean 0.9 h) P < 0.005). There were no important side-effects attributable to the bupivacaine administered. We conclude that intrapleural bupivacaine is an effective and reasonably safe method for obtaining analgesia in patients who have chest drain tubes inserted.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Injury
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Rocco A.
        • Reiestad F.
        • Gudman J.
        • et al.
        Intrapleural administration of local anesthetics for pain relief in patients with multiple rib fractures.
        Reg. Anaesth. 1987; 12: 10
        • Rosenberg H.
        • Scheinin B.M.-A.
        • Lepantalo M.J.A.
        • et al.
        Continuous intrapleural infusion of bupivacaine for analgesia after thoracotomy.
        Anesthesiology. 1987; 67: 811
        • Seltzer J.L.
        • Larijani G.E.
        • Goldberg M.E.
        • et al.
        Intrapleural bupivacaine — a kinetic and dynamic evaluation.
        Anesthesiology. 1987; 67: 798
        • Stromskrag K.E.
        • Reiestad F.
        • Holmqvist E.L.O.
        • et al.
        Intrapleural administration of 0.25%, 0.375%, and 0.5% bupivacaine with epinephrine after cholecystectomy.
        Anesth. Analg. 1988; 67: 430