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Research Article| Volume 17, ISSUE 3, P150-153, May 1986

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Alcohol and traumatic brain damage

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      Abstract

      Many head-injured patients have been drinking alcohol, and it has been suggested that the effect of a raised blood alcohol may be to potentiate brain damage after head injury. To investigate this, a study was carried out on 38 consecutive, recently head-injured patients admitted to the Glasgow Neurosurgical Unit. Conscious level, blood alcohol and serum creatine kinase BB (CKBB) were measured on admission (the latter by radioimmunoassay). Conscious level related strongly to outcome (χ2 = 11.678, P < 0.001), and serum CKBB (χ2 = 8.333, P < 0.01) but not to blood alcohol level. In patients with severe head injury admitted to a neurosurgical unit, coma is more likely to be due to the injury than to the blood alcohol level, and alcohol does not adversely affect outcome in such patients.
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      References

        • Flamm E.S.
        • Demopoulos H.B.
        • Seligman M.L.
        • et al.
        Ethanol potentiation of central nervous system trauma.
        J. Neurosurg. 1977; 46: 328
        • Galbraith S.
        • Murray W.R.
        • Patel A.R.
        • et al.
        The relationship between alcohol and head injury and its effect on conscious level.
        Br. J. Surg. 1973; 63: 128
        • Jagger J.
        • Fife D.M.D.
        • Vernberg K.
        • et al.
        Effect of alcohol intoxication on the diagnosis and apparent severity of brain injury.
        Neurosurgery. 1984; 15: 303
        • Jennett B.
        • Bond M.
        Assessment of outcome after severe brain damage.
        Lancet. 1975; i: 480
        • Phillips J.P.
        • Jones H.M.
        • Hitchcock R.
        • et al.
        Radioimmunoassay of serum creatine kinase BB as an index of brain damage after head injury.
        Br. Med. J. 1980; 281: 777
        • Steinbok P.
        • Thompson G.B.
        Metabolic disturbances after head injury: abnormalities of sodium and water balance with special reference to the effects of alcohol intoxication.
        Neurosurgery. 1978; 3: 9
        • Strang I.
        • MacMillan R.
        • Jennett W.B.
        Head injuries in accident and emergency departments in Scottish hospitals.
        Injury. 1978; 10: 154
        • Teasdale G.M.
        • Murray G.
        • Parker L.
        • et al.
        Adding up the Glasgow Coma Score.
        Acta Neurochir. (Wien). 1979; 28 (Suppl.): 13
        • Thomas D.G.T.
        • Rowan T.D.
        Lactic dehydrogenase isoenzymes following head injury.
        Injury. 1975; 7: 258
        • Thompson R.J.
        • Graham J.G.
        • McQueen I.N.F.
        • et al.
        Radioimmunoassay of brain type creatine kinase BB isoenzyme in human tissues and in serum of patients with neurological disorders.
        J. Neurol. Sci. 1980; 47: 241