Injury
Volume 41, Issue 6 , Pages 553-554 , June 2010

Bone defects and nonunions—What role does vascularity play in filling the gap?

  • H.C. Pape

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1 412 605 3219; fax: +1 412 687 0802.

References 

  1. Alt V, Donell ST, Chhabra A, et al. A health economic analysis of the use of rhBMP-2 in Gustilo-Anderson grade III open tibial fractures for the UK, Germany, and France. Injury. 2009;40(12):1269–1275
  2. Brownlow HC, Reed A, Simpson AH. Growth factor expression during the development of atrophic non-union. Injury. 2001;32(7):519–524
  3. Calori GM, Tagliabue L, Gala L, et al. Application of rhBMP-7 and platelet-rich plasma in the treatment of long bone non-unions: a prospective randomised clinical study on 120 patients. Injury. 2008;39(12):1391–1402
  4. Cancedda R, Giannoni P, Mastrogiacomo M. A tissue engineering approach to bone repair in large animal models and in clinical practice. Biomaterials. 2007;28(29):4240–4250
  5. Chung CY, Choi IH, Yoo WJ, et al. Distraction osteogenesis for segmental bone defect. Physeal change after acute bone shortening followed by gradual lengthening in a rabbit tibia model. Injury. 2005;36(12):1453–1459
  6. Dimitriou R, Tsiridis E, Giannoudis PV. Current concepts of molecular aspects of bone healing. Injury. 2005;36(12):1392–1404
  7. Donati D, Di BC, Lucarelli E, et al. OP-1 application in bone allograft integration: preliminary results in sheep experimental surgery. Injury. 2008;39(Suppl. 2):S65–S72
  8. Drosse I, Volkmer E, Capanna R, et al. Tissue engineering for bone defect healing: an update on a multi-component approach. Injury. 2008;39(Suppl. 2):S9–S20
  9. Geiger F, Bertram H, Berger I, et al. Vascular endothelial growth factor gene-activated matrix (VEGF165-GAM) enhances osteogenesis and angiogenesis in large segmental bone defects. J Bone Miner Res. 2005;20(11):2028–2035
  10. Giannoudis PV. Fracture healing and bone regeneration: autologous bone grafting or BMPs?. Injury. 2009;40(12):1243–1244
  11. Giannoudis PV, Einhorn TA. Bone morphogenetic proteins in musculoskeletal medicine. Injury. 2009;40(Suppl. 3):S1–S3
  12. Giannoudis PV, Einhorn TA, Marsh D. Fracture healing: the diamond concept. Injury. 2007;38(Suppl. 4):S3–S6
  13. Giannoudis PV, Einhorn TA, Schmidmaier G, Marsh D. The diamond concept—open questions. Injury. 2008;39(Suppl. 2):S5–S8
  14. Klaue K, Fengels I, Perren SM. Long-term effects of plate osteosynthesis: comparison of four different plates. Injury. 2000;31(Suppl. 2):S-62
  15. Masquelet AC, Begue T. The concept of induced membrane for reconstruction of long bone defects. Orthop Clin N Am. 2010;41:27–37
  16. Nasser NJ, Friedman A, Friedman M, et al. Guided bone regeneration in the treatment of segmental diaphyseal defects: a comparison between resorbable and non-resorbable membranes. Injury. 2005;36(12):1460–1466
  17. Oni OO. Protein immunohistochemistry as a means of unravelling the mysteries of fracture repair. Injury. 1995;26(8):523–525
  18. Parfitt AM. The mechanism of coupling: a role for the vasculature. Bone. 2000;26(4):319–323
  19. Petersen W, Wildemann B, Pufe T, et al. The angiogenic peptide pleiotrophin (PTN/HB-GAM) is expressed in fracture healing: an immunohistochemical study in rats. Arch Orthop Trauma Surg. 2004;124:603–607
  20. Pufe T, Wildemann B, Petersen W, et al. Quantitative measurement of the splice variants 120 and 164 of the angiogenic peptide vascular endothelial growth factor (VEGF) in the time flow of fracture healing: a study in rat. Cell Tissue Res. 2002;309:387–392
  21. Pufe T, Scholz-Ahrens KE, Franke AT, et al. The role of vascular endothelial growth factor in glucocorticoid-induced bone loss: evaluation in a minipig model. Bone. 2003;33(6):869–876
  22. Pufe T, Claassen H, Scholz-Ahrens KE, et al. Influence of estradiol on vascular endothelial growth factor expression in bone: a study in Gottingen miniature pigs and human osteoblasts. Calcif Tissue Int. 2007;80(3):184–191
  23. Schmidt-Rohlfing B, Tzioupis C, Menzel CL, Pape HC. Tissue engineering of bone tissue. Principles and clinical applications. Unfallchirurg. 2009;112(9):785–794
  24. Weiss S, Zimmermann G, Pufe T, et al. The systemic angiogenic response during bone healing. Arch Orthop Trauma Surg. 2009;129(7):989–997
  25. Westerhuis RJ, van Bezooijen RL, Kloen P. Use of bone morphogenetic proteins in traumatology. Injury. 2005;36(12):1405–1412
  26. Wiese A, Pape HC. Bone defects caused by high-energy injuries, bone loss, infected nonunions, and nonunions. Orthop Clin N Am. 2010;41:1–4
  27. Zaidi M, Alam AS, Bax BE, et al. Role of the endothelial cell in osteoclast control: new perspectives. Bone. 1993;14(2):97–102

PII: S0020-1383(10)00254-8

doi: 10.1016/j.injury.2010.04.001

Injury
Volume 41, Issue 6 , Pages 553-554 , June 2010