Injury
Volume 41, Issue 7 , Pages 724-730 , July 2010

Erythropoietin protects severe haemorrhagic shock-induced organ damage in conscious rats

  • Wen-Tien Wu

      Affiliations

    • Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
    • Department of Orthopedics, Tzu Chi General Hospital, Hualien, Taiwan
  • ,
  • Nien-Tsung Lin

      Affiliations

    • Institute of Microbiology, Immunology and Molecular Medicine, Tzu Chi University, Hualien, Taiwan
  • ,
  • Yi-Maun Subeq

      Affiliations

    • Department of Nursing, Tzu Chi University, Hualien, Taiwan
  • ,
  • Ru-Ping Lee

      Affiliations

    • Department of Nursing, Tzu Chi University, Hualien, Taiwan
  • ,
  • Ing-Ho Chen

      Affiliations

    • Department of Orthopedics, Tzu Chi General Hospital, Hualien, Taiwan
    • School of Medicine, Tzu Chi University, Hualien, Taiwan
  • ,
  • Bang-Gee Hsu

      Affiliations

    • School of Medicine, Tzu Chi University, Hualien, Taiwan
    • Division of Nephrology, Tzu Chi General Hospital, Hualien, Taiwan
    • Corresponding Author InformationCorresponding author at: School of Medicine, Tzu Chi University, No. 701, Section 3, Chung Yang Rd. 97004, Hualien, Taiwan. Tel.: +886 3 8561825; fax: +886 3 8577161.

,Accepted 8 December 2009.

References 

  1. Abdelrahman M, Sharples EJ, McDonald MC, et al. Erythropoietin attenuates the tissue injury associated with hemorrhagic shock and myocardial ischemia. Shock. 2004;22:63–69
  2. Abraham E, Jesmok G, Tuder R, et al. Contribution of tumor necrosis factor-alpha to pulmonary cytokine expression and lung injury after hemorrhage and resuscitation. Crit Care Med. 1995;23:1319–1326
  3. Algin MC, Hacioglu A, Yaylak F, et al. The role of erythropoietin in hemorrhagic shock-induced liver and renal injury in rats. Adv Ther. 2008;25:1353–1374
  4. Arcasoy MO. The non-haematopoietic biological effects of erythropoietin. Br J Haematol. 2008;141:14–31
  5. Bahrami S, Yao YM, Leichtfried G, et al. Significance of TNF in hemorrhage-related hemodynamic alterations, organ injury, and mortality in rats. Am J Physiol. 1997;272:H2219–H2226
  6. Brundage SI, Zautke NA, Holcomb JB, et al. Interleukin-6 infusion blunts proinflammatory cytokine production without causing systematic toxicity in a swine model of uncontrolled hemorrhagic shock. J Trauma. 2004;57:970–977
  7. Chen CH, Lee RP, Wu WT, et al. Fluvastatin attenuate endotoxin shock induced organ damage in conscious rats. Resuscitation. 2007;74:166–174
  8. Childs EW, Wood JG, Smalley DM, et al. Leukocyte adherence and sequestration following hemorrhagic shock and total ischemia in rats. Shock. 1999;11:248–252
  9. Deitch EA, Xu DZ, Franko L, et al. Evidence favoring the role of the gut as a cytokine generating organ in rats subjected to hemorrhagic shock. Shock. 1994;1:141–146
  10. Doig CJ, Sutherland LR, Sandham JD, et al. Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients. Am J Respir Crit Care Med. 1998;158:444–451
  11. Fliser D, Bahlmann FH. Erythropoietin and the endothelium—a promising link?. Eur J Clin Invest. 2008;38:457–461
  12. Guarini S, Altavilla D, Cainazzo MM, et al. Efferent vagal fibre stimulation blunts nuclear factor-kappaB activation and protects against hypovolemic hemorrhagic shock. Circulation. 2003;107:1189–1194
  13. Guneli E, Cavdar Z, Islekel H, et al. Erythropoietin protects the intestine against ischemia/reperfusion injury in rats. Mol Med. 2007;13:509–517
  14. Gutierrez G, Reines HD, Wulf-Gutierrez ME. Clinical review: hemorrhagic shock. Crit Care. 2004;8:373–381
  15. Ivatury RR, Simon RJ, Islam S, et al. A prospective randomized study of endpoints of resuscitation after major trauma: global oxygen transport indices versus organ-specific gastric mucosal pH. J Am Coll Surg. 1996;183:145–154
  16. Jelkmann W. Molecular biology of erythropoietin. Intern Med. 2004;43:649–659
  17. Johnson DW, Forman C, Vesey DA. Novel renoprotective actions of erythropoietin: new uses for an old hormone. Nephrol. 2006;11:306–312
  18. Kauvar DS, Lefering R, Wade CE. Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations. J Trauma. 2006;60(6 Suppl.):S3-11
  19. Keel M, Trentz O. Pathophysiology of polytrauma. Injury. 2005;36:691–709
  20. Konstantinopoulos PA, Karamouzis MV, Papavassiliou AG. Selective modulation of the erythropoietic and tissue-protective effects of erythropoietin: time to reach the full therapeutic potential of erythropoietin. Biochim Biophys Acta. 2007;1776:1–9
  21. Kumral A, Baskin H, Duman N, et al. Erythropoietin protects against necrotizing enterocolitis of newborn rats by the inhibiting nitric oxide formation. Biol Neonate. 2003;84:325–329
  22. Lee CC, Chang IJ, Yen ZS, et al. Effect of different resuscitation fluids on cytokine response in a rat model of hemorrhagic shock. Shock. 2005;24:177–181
  23. Lee CC, Lee RP, Subeq YM, et al. Fluvastatin attenuates severe hemorrhagic shock-induced organ damage in rats. Resuscitation. 2009;80:372–378
  24. Lee CJ, Subeq YM, Lee RP, et al. Low-dose propofol ameliorates hemorrhagic shock induced organ damage in conscious rats. Clin Exp Pharmacol Physiol. 2008;35:766–774
  25. Li Y, Takemura G, Okada H, et al. Reduction of inflammatory cytokine expression and oxidative damage by erythropoietin in chronic heart failure. Cardiovas Res. 2006;71:684–694
  26. Luft FC. Lactic acidosis update for critical care clinicians. J Am Soc Nephrol. 2001;12(17 Suppl.):S15–S19
  27. Luyer MD, Greve JW, Hadfoune M, et al. Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve. J Exp Med. 2005;202:1023–1029
  28. Mizock BA, Falk JL. Lactic acidosis in critical illness. Crit Care Med. 1992;20:80–93
  29. Mok YY, Moore PK. Hydrogen sulphide is pro-inflammatory in haemorrhagic shock. Inflamm Res. 2008;57:512–518
  30. Peng TC, Liao KW, Lai HL, et al. The physiological changes of cumulative hemorrhagic shock in conscious rats. J Biomed Sci. 2006;13:385–394
  31. Rixen D, Siegel JH. Bench-to-bedside review: oxygen debt and its metabolic correlates as quantifiers of the severity of hemorrhagic and post-traumatic shock. Crit Care. 2005;9:441–453
  32. Rosas-Ballina M, Tracey KJ. Cholinergic control of inflammation. J Intern Med. 2009;265:663–679
  33. Rossert J, Eckardt KUJ. Erythropoietin receptors: their role beyond erythropoiesis. Nephrol Dial Transplant. 2005;20:1025–1028
  34. Rushing GD, Britt LD. Reperfusion injury after hemorrhage: a collective review. Ann Surg. 2008;247:929–937
  35. Schmeding M, Neumann UP, Boas-Knoop S, et al. Erythropoietin reduces ischemia-reperfusion injury in the rat liver. Eur Surg Res. 2007;39:189–197
  36. Senthil M, Watkins A, Barlos D, et al. Intravenous injection of trauma-hemorrhagic shock mesenteric lymph causes lung injury that is dependent upon activation of the inducible nitric oxide synthase pathway. Ann Surg. 2007;246:822–830
  37. Sharples EJ, Thiemermann C, Yaqoob MM. Mechanisms of disease: cell death in acute renal failure and emerging evidence for a protective role of erythropoietin. Nat Clin Pract Nephrol. 2005;1:87–97
  38. Villa P, Bigini P, Mennini T, et al. Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. J Exp Med. 2003;198:971–975
  39. Watters JM, Tieu BH, Todd SR, et al. Fluid resuscitation increases inflammatory gene transcription after traumatic injury. J Trauma. 2006;61:300–308
  40. Wu H, Dong G, Liu H, et al. Erythropoietin attenuates ischemia-reperfusion induced lung injury by inhibiting tumor necrosis factor-alpha and matrix metalloproteinase-9 expression. Eur J Pharmacol. 2009;602:406–412
  41. Wu H, Ren B, Zhu J, et al. Pretreatment with recombined human erythropoietin attenuates ischemia-reperfusion-induced lung injury in rats. Eur J Cardiothorac Surg. 2006;29:902–907
  42. Xu DZ, Lu Q, Adams CA, et al. Trauma-hemorrhagic shock-induced up-regulation of endothelial cell adhesion molecules is blunted by mesenteric lymph duct ligation. Crit Care Med. 2004;32:760–765

PII: S0020-1383(09)00646-9

doi: 10.1016/j.injury.2009.12.006

Injury
Volume 41, Issue 7 , Pages 724-730 , July 2010