Injury
Volume 41, Issue 7 , Pages 693-701 , July 2010

A novel nano-composite multi-layered biomaterial for treatment of osteochondral lesions: Technique note and an early stability pilot clinical trial

  • E. Kon

      Affiliations

    • IX Division and Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Via Di Barbiano, 1/10, 40136 Bologna, Italy
    • ,
  • M. Delcogliano

      Affiliations

    • San Carlo di Nancy Hospital, Via Aurelia 275, 00165 Rome, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 335 701 8921; fax: +39 069 727 3935.
    • ,
  • G. Filardo

      Affiliations

    • IX Division and Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Via Di Barbiano, 1/10, 40136 Bologna, Italy
    • ,
  • D. Pressato

      Affiliations

    • Fin-Ceramica Faenza S.p.A., Faenza, Italy
    • ,
  • M. Busacca

      Affiliations

    • Rizzoli Orthopaedic Institute, Bologna, Italy
    • ,
  • B. Grigolo

      Affiliations

    • Rizzoli Orthopaedic Institute, Bologna, Italy
    • ,
  • G. Desando

      Affiliations

    • Rizzoli Orthopaedic Institute, Bologna, Italy
    • ,
  • M. Marcacci

      Affiliations

    • IX Division and Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Via Di Barbiano, 1/10, 40136 Bologna, Italy

,Accepted 23 November 2009.

References 

  1. Adachi N, Ochi M, Deie M, et al. Lateral compartment osteoarthritis of the knee after mensiscectomy treated by the transplantation of tissue-engineered cartilage and osteochondral plug. Arthroscopy. 2006;22(January (1)):107–112
  2. Behrens P, Bitter T, Kurz B, et al. Matrix-associated autologous chondrocyte transplantation/implantation (MATC/MACI)-5-year follow-up. Knee. 2006;13:194–202
  3. Buma P, Pieper JS, van Tienen T, et al. Cross-linked type I and type II collagenous matrices for the repair of full-thickness articular cartilage defects—a study in rabbits. Biomaterials. 2003;24:3255–3263
  4. Hoemann CD, Hurtig M, Rossomacha E, et al. Chitosan-glycerol phosphate/blood implants improve hyaline cartilage repair in ovine microfracture defects. J Bone Joint Surg Am. 2005;87:2671–2686
  5. ICRS Cartilage Injury Evaluation Package 2000, available at http://www.cartilge.org/files/ICRScontentmanagement/ICRS.evaluationn.pdf.
  6. Jiang CC, Chiang H, Liao CJ, et al. Repair of porcine articular cartilage defect with a biphasic osteochondral composite. J Orthop Res. 2007;25(October (10)):1277–1290
  7. Jubel A, Andermahr J, Schiffer G, et al. Transplantation of de novo scaffold-free cartilage implants into sheep knee chondral defects. Am J Sports Med. 2008;36(August (8)):1555–1564
  8. Kon E, Delcogliano M, Filardo G, et al. Novel nano-composite biomaterial for osteochondral tissue engineering. Osteoarthritis Cartilage. 2007;15(Suppl. 2):B76–B77
  9. Kon E, Delcogliano M, Filardo G, et al. Second generation issue in cartilage repair. Sports Med Arthrosc. 2008;16(December (4)):221–229
  10. Marcacci M, Berruto M, Brocchetta D, et al. Articular cartilage engineering with hyalograft C: 3-year clinical results. Clin Orthop Relat Res. 2005;(June (435)):96–105
  11. Marcacci M, Kon E, Zaffagnini S, et al. Arthroscopic second generation autologous chondrocyte implantation. Knee Surg Sports Traumatol Arthrosc. 2007;15(May (5)):610–619
  12. Marlovits S, Striessnig G, Kutscha-Lissberg F, et al. Early postoperative adherence of matrix-induced autologous chondrocyte implantation for the treatment of full-thickness cartilage defects of the femoral condyle. Knee Surg Sports Traumatol Arthrosc. 2005;13:451–457
  13. Marlovits S, Striessnig G, Resinger CT, et al. Definition of pertinent parameters for the evaluation of articular cartilage repair tissue with high-resolution magnetic resonance imaging. Eur J Radiol. 2004;52(December (3)):310–319
  14. Marlovits S, Vekszler G, Resinger C, et al. Clinical and radiological outcome of matrix induced autologous chondrocyte implantation (MACI) after 24 months. Osteoarthritis Cartilage. 2007;15(Suppl. B, P68):105
  15. Niederauer GG, Slivka MA, Leatherbury NC, et al. Evaluation of multiphase implants for repair of focal osteochondral defects in goats. Biomaterials. 2000;21:2561–2574
  16. Ossendorf C, Kaps C, Kreuz P, et al. Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results. Arthritis Res Ther. 2007;9(2):R41
  17. Schagemann JC, Erggelet C, Chung HW, et al. Cell-laden and cell-free biopolymer hydrogel for the treatment of osteochondral defects in a sheep model. Tissue Eng A. 2008;
  18. Tampieri A, Celotti G, Landi E, et al. Biologically inspired synthesis of bone-like composite: self-assembled collagen fibers/hydroxyapatite nanocrystals. J Biomed Mater Res A. 2003;67:618–625
  19. Tampieri A, Sandri M, Landi E, et al. Design of graded Biomimetic osteochondral composite scaffold. Biomaterials. 2008;29(September (26)):3539–3546
  20. Tratting S, Mamisch TC, Pinker K, et al. Differentiating normal hyaline cartilage from post-surgical repair tissue using fast gradient echo imaging in delayed gadolinium-enhanced MRI (dGEMRIC) at 3Tesla. Eur Radiol. 2008;18(June (6)):1251–1259
  21. Williams RJ, Gamradt SC. Articular cartilage repair using a resorbable matrix scaffold. Instr Course Lect. 2008;57:563–571
  22. Zheng MH, Willers C, Wood D. Matrix-induced autologous chondrocytes implantation (MACI®): biological and clinical evaluation. Basic science, clinical repair and reconstruction of articular cartilage defects: current status and prospects. 2006;pp. 517–528 [chapter 54]

PII: S0020-1383(09)00623-8

doi: 10.1016/j.injury.2009.11.014

Injury
Volume 41, Issue 7 , Pages 693-701 , July 2010

Article Tools

* Image Usage & Resolution