Injury
Volume 41, Issue 7 , Pages 680-686 , July 2010

Rh-BMP-2 in distraction osteogenesis: Dose effect and premature consolidation

  • Frédéric Sailhan

      Affiliations

    • Department of Orthopaedic Surgery, Hôpital Cochin, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France
    • Corresponding Author InformationCorresponding author. Tel.: +33 688234157.
  • ,
  • Baptiste Gleyzolle

      Affiliations

    • Department of Animal Experimental Surgery, National Veterinary School of Lyon, Marcy-l’Etoile, France
  • ,
  • Roger Parot

      Affiliations

    • Department of Pediatric Orthopaedics, Clinique du Val d’Ouest, Lyon, France
  • ,
  • Henri Guerini

      Affiliations

    • Department of Radiology, Hôpital Cochin, Paris, France
  • ,
  • Eric Viguier

      Affiliations

    • Department of Animal Experimental Surgery, National Veterinary School of Lyon, Marcy-l’Etoile, France

,Accepted 5 October 2009.

References 

  1. Aldegheri R, Renzi-Brivio L, Agostini S. The callotasis method of limb lengthening. Clin Orthop. 1989;241:137–145
  2. Apivatthakakul T, Arpornchayanon O. Minimally invasive plate osteosynthesis (MIPO) combined with distraction osteogenesis in the treatment of bone defects. A new technique of bone transport: a report of two cases. Injury. 2002;33(5):460–465
  3. Campbell JT, Kaplan FS, De Bastiani G, et al. The bone morphogenetic protein family and osteogenesis. Calcif Tissue Int. 1992;50(3):283–289
  4. Campisi P, Hamdy RC, Lauzier D, et al. Expression of bone morphogenetic proteins during mandibular distraction osteogenesis. Plast Reconstr Surg. 2003;111(1):201–208[discussion 209–10]
  5. Chaudhary LR, Hofmeister AM, Hruska KA. Differential growth factor control of bone formation through osteoprogenitor differentiation. Bone. 2004;34(3):402–411
  6. Cheung LK, Zheng LW. Effect of recombinant human bone morphogenetic protein-2 on mandibular distraction at different rates in an experimental model. J Craniofac Surg. 2006;17(1):100–108[discussion 109–10]
  7. Chotel F, Braillon P, Sailhan F, et al. Bone stiffness in children. Part II. Objectives criteria for children to assess healing during leg lengthening. J Pediatr Orthop. 2008;28(5):538–543
  8. Codivilla A. On the means of lengthening, in the lower limbs, the muscles and tissues which are shortened through deformity. Am J Orthop Surg. 1905;2:353–369
  9. Cook SD, Barrack RL, Santman M, et al. The Otto Aufranc Award. Strut allograft healing to the femur with recombinant human osteogenic protein-1. Clin Orthop Relat Res. 2000;381:47–57
  10. De Bastiani G, Aldegheri R, Renzi-Brivio L, Trivella G. Limb lengthening by callus distraction (callotasis). J Pediatr Orthop. 1987;7(2):129–134
  11. Hamdy RC, Amako M, Beckman L, et al. Effects of osteogenic protein-1 on distraction osteogenesis in rabbits. Bone. 2003;33(2):248–255
  12. Haque T, Hamade F, Alam N, et al. Characterizing the BMP pathway in a wild type mouse model of distraction osteogenesis. Bone. 2008;42(6):1144–1153
  13. Hogan BL. Bone morphogenetic proteins in development. Curr Opin Genet Dev. 1996;6(4):432–438
  14. Hogan BL. Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 1996;10(13):1580–1594
  15. Ilizarov GA. The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. Clin Orthop. 1989;238:249–281
  16. Ilizarov GA. The tension-stress effect on the genesis and growth of tissues. Part II. The influence of the rate and frequency of distraction. Clin Orthop. 1989;239:263–285
  17. Kanellopoulos AD, Soucacos PN. Management of nonunion with distraction osteogenesis. Injury. 2006;37(Suppl. 1):S51–S55
  18. Kirker-Head CA, Gerhart TN, Armstrong R, et al. Healing bone using recombinant human bone morphogenetic protein 2 and copolymer. Clin Orthop. 1998;349:205–217
  19. Kirker-Head CA, Gerhart TN, Schelling SH, et al. Long-term healing of bone using recombinant human bone morphogenetic protein 2. Clin Orthop. 1995;318:222–230
  20. Korzinek K, Tepic S, Perren SM. Limb lengthening and three-dimensional deformity corrections. A retrospective clinical study. Arch Orthop Trauma Surg. 1990;109(6):334–340
  21. Lammens J, Liu Z, Aerssens J, et al. Distraction bone healing versus osteotomy healing: a comparative biochemical analysis. J Bone Miner Res. 1998;13(2):279–286
  22. Li G, Bouxsein ML, Luppen C, et al. Bone consolidation is enhanced by rhBMP-2 in a rabbit model of distraction osteogenesis. J Orthop Res. 2002;20(4):779–788
  23. Li G, Simpson AH, Kenwright J, Triffitt JT. Assessment of cell proliferation in regenerating bone during distraction osteogenesis at different distraction rates. J Orthop Res. 1997;15(5):765–772
  24. Maffulli N, Cheng JC, Sher A, et al. Bone mineralization at the callotasis site after completion of lengthening. Bone. 1999;25(3):333–338
  25. Mizumoto Y, Moseley T, Drews M, et al. Acceleration of regenerate ossification during distraction osteogenesis with recombinant human bone morphogenetic protein-7. J Bone Joint Surg Am. 2003;85-A(Suppl. 3):124–130
  26. Moseley CF. Assessment and prediction in leg-length discrepancy. Instr Course Lect. 1989;38:325–330
  27. Moseley CF. Leg lengthening. A review of 30 years. Clin Orthop. 1989;247:38–43
  28. Paley D. Problems, obstacles, and complications of limb lengthening by the Ilizarov technique. Clin Orthop Relat Res. 1990;250:81–104
  29. Paramore CG, Lauryssen C, Rauzzino MJ, et al. The safety of OP-1 for lumbar fusion with decompression—a canine study. Neurosurgery. 1999;44(5):1151–1155[discussion 1155–6]
  30. Rauch F, Lauzier D, Croteau S, et al. Temporal and spatial expression of bone morphogenetic protein-2, -4, and -7 during distraction osteogenesis in rabbits. Bone. 2000;27(3):453–459
  31. Reichel H, Haunschild M, Kruger T, Hein W. Tibial lengthening. Epiphyseal and callus distraction compared in 39 patients with 3–14 years follow-up. Acta Orthop Scand. 1996;67(4):355–358
  32. Sailhan F, Chotel F, Chousta A, et al. Unexpected absence of effect of rhBMP-7 on distraction osteogenesis. Clin Orthop Relat Res. 2007;457:227–234
  33. Sakou T. Bone morphogenetic proteins: from basic studies to clinical approaches. Bone. 1998;22(6):591–603
  34. Salkeld SL, Patron LP, Barrack RL, Cook SD. The effect of osteogenic protein-1 on the healing of segmental bone defects treated with autograft or allograft bone. J Bone Joint Surg Am. 2001;83-A(6):803–816
  35. Sangkaew C. Distraction osteogenesis for the treatment of post traumatic complications using a conventional external fixator. A novel technique. Injury. 2005;36(1):185–193
  36. Sato M, Ochi T, Nakase T, et al. Mechanical tension-stress induces expression of bone morphogenetic protein (BMP)-2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA, during distraction osteogenesis. J Bone Miner Res. 1999;14(7):1084–1095
  37. Urist MR. Bone: formation by autoinduction, 1965. Clin Orthop Relat Res. 2002;395:4–10
  38. Wang ZG, Hu J, Zou SJ, et al. Recombinant human BMP-2 accelerates bone formation of mandibular distraction osteogenesis in rabbits. Hua Xi Kou Qiang Yi Xue Za Zhi. 2004;22(3):186–188
  39. Wozney JM. The bone morphogenetic protein family and osteogenesis. Mol Reprod Dev. 1992;32(2):160–167
  40. Wozney JM. Bone morphogenetic proteins. Prog Growth Factor Res. 1989;1(4):267–280
  41. Yasko AW, Lane JM, Fellinger EJ, Rosen V, Wozney JM, Wang EA. The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). A radiographic, histological, and biomechanical study in rats. J Bone Joint Surg Am. 1992;74(5):659–670
  42. Yazawa M, Kishi K, Nakajima H, Nakajima T. Expression of bone morphogenetic proteins during mandibular distraction osteogenesis in rabbits. J Oral Maxillofac Surg. 2003;61(5):587–592

PII: S0020-1383(09)00533-6

doi: 10.1016/j.injury.2009.10.010

Injury
Volume 41, Issue 7 , Pages 680-686 , July 2010