Injury
Volume 40, Issue 12 , Pages 1269-1275 , December 2009

A health economic analysis of the use of rhBMP-2 in Gustilo–Anderson grade III open tibial fractures for the UK, Germany, and France

  • Volker Alt

      Affiliations

    • Department of Trauma Surgery Giessen University Hospital Giessen-Marburg, Site Giessen, Rudolf-Buchheim-Str. 7, 35385 Giessen, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 641 99 44 601; fax: +49 641 99 44 666.
    • ,
  • Simon T. Donell

      Affiliations

    • Faculty of Health, University of East Anglia, Norwich NR4 7SY, UK
    • ,
  • Amit Chhabra

      Affiliations

    • Medtronic Sàrl, Tolochenaz, Switzerland
    • ,
  • Anthony Bentley

      Affiliations

    • Abacus International, Bicester, UK
    • ,
  • Alexander Eicher

      Affiliations

    • Department of Trauma Surgery Giessen University Hospital Giessen-Marburg, Site Giessen, Rudolf-Buchheim-Str. 7, 35385 Giessen, Germany
    • ,
  • Reinhard Schnettler

      Affiliations

    • Department of Trauma Surgery Giessen University Hospital Giessen-Marburg, Site Giessen, Rudolf-Buchheim-Str. 7, 35385 Giessen, Germany

,Accepted 9 February 2009.

References 

  1. Alt V, Eicher A, Bitschnau A, Schnettler R. Cost-benefit analysis of the use of rhBMP-2 in open tibial fractures: savings from a health insurer's perspective. Unfallchirurg. 2006;109:463–470[German]
  2. Alt V, Heissel A. Economic considerations for the use of recombinant human Bone Morphogenetic Protein-2 in open tibial fractures in Europe: the German model. Curr Med Res Opin. 2006;22(Suppl. 1):19–22
  3. Court-Brown CM. Reamed intramedullary tibial nailing: an overview and analysis of 1106 cases. J Orthop Trauma. 2004;18:96–101
  4. Dahabreh Z, Dimitriou R, Giannoudis PV. Health-economics: a cost analysis of treatment of persistent fracture non-union using Bone Morphogenetic Protein-7. Injury. 2007;38:371–377
  5. Eggli S, Scholl E, Hertel R. Versorgung von IIIB offenen Unterschenkelfrakturen durch Frühosteosynthese und lokalen Muskellappen. Unfallchirurg. 1998;101:674–683
  6. Garrison KR, Donell S, Ryder J, et al. Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: a systematic review. Health Technol Assess. 2007;11(30):
  7. Govender S, Csimma C, Genant HK, Valentin-Opran A, by the BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group. Recombinant human Bone Morphogenetic Protein-2 for treatment of open tibial fractures. A prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg 2002;84-A:2123–34.
  8. Jones AL. Recombinant human Bone Morphogenic Protein-2 in fracture care. J Orthop Trauma. 2005;19(10):S23–S25
  9. Jones AL, Swiontkowski MF, Polly DW, et al. Use of rhBMP-2 in the treatment of open tibial shaft fractures: do improved clinical outcomes outweigh the additional expense of rhBMP-2?. In: Orthopaedic Trauma Association Annual Meeting. Hollywood, FL. 2004;[Scientific Poster 15]
  10. Maetzel A, Li L. The economic burden of low back pain: a review of studies published between 1996 and 2001. Best Pract Res Clin Rheumatol. 2002;16:23–30
  11. Malik MH, Harwood P, Diggle P, Khan SA. Factors affecting rates of infection and nonunion in intramedullary nailing. J Bone Joint Surg. 2004;86-B:556–560
  12. Maniadakis N, Gray A. The economic burden of back pain in the UK. Pain. 2000;84:95–103
  13. No authors listed. The management of open tibial fractures. Published by: British Orthopaedic Association and British Association of Plastic Surgeons. www.boa.ac.uk/site/showpubliactions.aspx?ID=59 (last visited: 29/10/08).
  14. No authors listed. http://www.legifrance.gouv.fr/ (last visited: 29/10/08).
  15. No authors listed. www.dh.gov.uk (last visited: 29/10/08).
  16. No author listed. www.oanda.com. (last visited: 29/10/08).
  17. No authors listed. EUROSTAT. Retrieved on Wikipedia in May 2008.
  18. No authors listed. www.cebm.net/levels_of_evidence.asp (last visited: 29/10/08).
  19. Sanders R, Jersinovich I, Anglen J, et al. The treatment of open tibial shaft fractures using an interlocked intramedullary nail without reaming. J Orthop Trauma. 1994;8:504–510
  20. Schröder K. International Comparison of Labor Costs in Manufactuing. IW-Trends – Vierteljahresschrift zur empirischen Wirtschaftsforschung aus dem Institut der deutschen Wirtschaft Köln, 2006. p. 1–15.
  21. Seferlis T, Lindholm L, Nemeth G. Cost-minimisation analysis of three conservative treatment programmes in 180 patients sick-listed for acute low-back pain. Scand J Prim Health Care. 2000;18:53–57
  22. Soegaard R, Christensen FB. Health economic evaluation in lumbar spinal fusion: a systematic literature review anno 2005. Eur Spine J. 2006;15:1165–1173
  23. Sprague S, Bhandhari M. An economic evaluation of early versus delayed operative treatment in patients with closed tibial shaft fractures. Arch Orthop Trauma Surg. 2002;122:315–323
  24. Szucs Th. Economic evaluation of technologies in health care. In:  Szucs T,  Haverich A,  Odar J editor. Economics of surgical procedures. Heidelbergand: JA Barth; 2000;p. 3–4
  25. Udvarhelyi IS, Colditz GA, Rai A, Epstein AM. Cost-effectiveness and cost-benefit analyses in the medical literature. Are the methods being used correctly?. Ann Intern Med. 1992;116:238–244

PII: S0020-1383(09)00151-X

doi: 10.1016/j.injury.2009.02.007

Injury
Volume 40, Issue 12 , Pages 1269-1275 , December 2009

Article Tools