Injury
Volume 40, Issue 8 , Pages 868-872 , August 2009

Effects of bilirubin ditaurate overload on canalicular membrane function and ultrastructure of the pig liver

  • Knut J. Labori

      Affiliations

    • Department of Gastroenterological Surgery, Ullevaal University Hospital, 0407 Oslo, Norway
    • Institute for Experimental Medical Research, Ullevaal University Hospital, 0407 Oslo, Norway
    • Corresponding Author InformationCorresponding author at: Department of Gastroenterological Surgery, Ullevaal University Hospital, Kirkeveien 166, N-0407 Oslo, Norway. Tel.: +47 22118080; fax: +47 22119558.
    • ,
  • Torstein Lyberg

      Affiliations

    • Center for Clinical Research, Ullevaal University Hospital, 0407 Oslo, Norway
    • ,
  • Morten G. Raeder

      Affiliations

    • Department of Gastroenterological Surgery, Ullevaal University Hospital, 0407 Oslo, Norway
    • Institute for Experimental Medical Research, Ullevaal University Hospital, 0407 Oslo, Norway

,Accepted 17 November 2008.

References 

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  7. Labori KJ, Raeder MG. Diagnostic approach to the patient with jaundice following trauma. Scand J Surg. 2004;93:176–183
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  13. Ostrow JD, Pascolo L, Tiribelli C. Mechanisms of bilirubin neurotoxicity. Hepatology. 2002;35:1277–1280
  14. Oude Elferink RP, Paulusma CC, Groen AK. Hepatocanalicular transport defects: pathophysiologic mechanisms of rare diseases. Gastroenterology. 2006;130:908–925
  15. Schenker S, Hoyumpa AM. Bilirubin toxicity to the brain (kernicterus) and other tissues. In:  Ostrow JD editors. Bile pigments and jaundice. Molecular and medical aspects. New York: Markel Dekker, Inc.; 1986;p. 407–410
  16. Schmid M, Hefti ML, Gattiker R, et al. Benign postoperative intrahepatic cholestasis. N Engl J Med. 1965;272:545–550
  17. Verkade HJ. Inhibition of biliary phospholipid and cholesterol secretion by organic anions affects bile canalicular membrane composition and fluidity. J Gastroenterol. 2000;35:481–485
  18. Verkade HJ, Havinga R, Gerding A, et al. Mechanism of bile acid-induced biliary lipid secretion in the rat: effect of conjugated bilirubin. Am J Physiol. 1993;264:G462–G469
  19. Verkade HJ, Vonk RJ, Kuipers F. New insights into the mechanism of bile acid-induced biliary lipid secretion. Hepatology. 1995;21:1174–1189
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PII: S0020-1383(08)00533-0

doi: 10.1016/j.injury.2008.11.017

Injury
Volume 40, Issue 8 , Pages 868-872 , August 2009

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